A TR(I)P to pruritus research: Role of TRPV3 in inflammation and itch

Martin Steinhoff, T. Bíró

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalJournal of Investigative Dermatology
Volume129
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Pruritus
Skin
Dermatitis
Inflammation
Ion Channels
Research
Histamine
Transient Receptor Potential Channels
Eczema
Keratinocytes
Skin Diseases
Leukocytes
Temperature
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

A TR(I)P to pruritus research : Role of TRPV3 in inflammation and itch. / Steinhoff, Martin; Bíró, T.

In: Journal of Investigative Dermatology, Vol. 129, No. 3, 03.2009, p. 531-535.

Research output: Contribution to journalArticle

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