A trace element preparation containing zinc increases the production of interleukin-6 in human monocytes and glial cells

András Falus, József Béres

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9 Citations (Scopus)

Abstract

The in vitro effects of a trace element preparation (Beres Drops Plus, BDP) on the biosynthesis of inflammatory cytokines interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) were studied in human peripheral monocytes. The production of IL-6 was studied in a glioblastoma cell line, SKMG-4, as well. The trace element preparation BDP significantly stimulated both the constitutive and the endotoxin or IL-1 induced IL-6 production in monocytes or in glial cells, respectively, but revealed no or only modest effect on IL-1 and TNF-α production of monocytes. Moreover, BDP was able to reduce the inhibitory effect of a synthetic corticosteroid, dexamethasone on the biosynthesis of IL-6. The positive effect of the trace element preparation on the IL-6 production of monocytes from rheumatoid arthritis (RA) patients is comparable, to that of on the monocytes from healthy individuals, and similarly to healthy individuals was negligible on the IL-1 and TNF-α production. The detailed analysis of the composition of the preparation suggested, that the major active component in the stimulation of IL-6 production is Zn, but for the complete effect other trace elements are also required.

Original languageEnglish
Pages (from-to)293-301
Number of pages9
JournalBiological Trace Element Research
Volume51
Issue number3
DOIs
Publication statusPublished - Jan 1 1996

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Keywords

  • Trace element
  • Zn
  • glioblastoma
  • interleukin-1
  • interleukin-6
  • lipopolysaccharide
  • monocyte
  • tumor necrosis factor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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