A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

Máté Kicsák, Miklós Bege, Ilona Bereczki, Magdolna Csávás, Mihály Herczeg, Zoltán Kupihár, L. Kovács, A. Borbás, P. Herczegh

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A new reagent system consisting of a Lewis acid such as BF3·Et2O or Cu(OTf)2, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives. The method is compatible with acetyl, silyl, acetal and Fmoc groups.

Original languageEnglish
Pages (from-to)3190-3192
Number of pages3
JournalOrganic and Biomolecular Chemistry
Issue number12
Publication statusPublished - 2016


ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

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