A teratological study of aminoglycoside antibiotic treatment during pregnancy

E. Czeizel, M. Rockenbauer, J. Olsen, H. T. Sorensen

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The aim of this study was to investigate the teratogenicity of aminoglycoside antibiotics, such as parenteral gentamicin, streptomycin, tobramycin and oral neomycin, during pregnancy. Pair analysis of cases with congenital abnormalities and matched healthy controls was carried out. The setting was the population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-96. In total, 38,151 pregnant who had newborn infants without any defects (control group) and 22,865 pregnant women who had foetuses or newborns with congenital abnormalities were included in the study. 38 (0.16‰) and 42 (0.11‰) pregnant women in the case and control groups, respectively, were treated the aminoglycosides studied. A teratogenic potential of gentamicin and neomycin was not indicated by a comparison of the occurrence of aminoglycoside antibiotic treatments in the total control group as referent with the figures of different congenital abnormality groups. In addition, the case-control pair analysis during the second- third months of pregnancy of pregnancy did not show a teratogenic risk of gentamicin and neomycin. The conclusion teratogenic risk to the foetus, when restricted to structural developmental disturbances.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume32
Issue number3
Publication statusPublished - 2000

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Aminoglycosides
Neomycin
Gentamicins
Anti-Bacterial Agents
Pregnancy
Control Groups
Pregnant Women
Fetus
Newborn Infant
Tobramycin
Streptomycin
Therapeutics
Population

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

A teratological study of aminoglycoside antibiotic treatment during pregnancy. / Czeizel, E.; Rockenbauer, M.; Olsen, J.; Sorensen, H. T.

In: Scandinavian Journal of Infectious Diseases, Vol. 32, No. 3, 2000, p. 309-313.

Research output: Contribution to journalArticle

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