A synthetic and in silico study on the highly regioselective Diels-Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin

Zsolt Fejes, Attila Mándi, István Komáromi, László Majoros, Gyula Batta, Pál Herczegh

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2 Citations (Scopus)


The tetraenic macrolide antibiotic natamycin and the pentaenic macrolide flavofungin gave monoadducts on Diels-Alder reaction with 4-phenyl-1,2,4- triazoline-3,5-dione. The regioselectivity of the reaction as well as the conformation of the products was studied using theoretical calculations.

Original languageEnglish
Pages (from-to)4968-4971
Number of pages4
JournalTetrahedron Letters
Issue number38
Publication statusPublished - 2010


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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