A synthetic and in silico study on the highly regioselective Diels-Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin

Zsolt Fejes, Attila Mándi, I. Komáromi, László Majoros, G. Batta, P. Herczegh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The tetraenic macrolide antibiotic natamycin and the pentaenic macrolide flavofungin gave monoadducts on Diels-Alder reaction with 4-phenyl-1,2,4- triazoline-3,5-dione. The regioselectivity of the reaction as well as the conformation of the products was studied using theoretical calculations.

Original languageEnglish
Pages (from-to)4968-4971
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number38
DOIs
Publication statusPublished - 2010

Fingerprint

Natamycin
Antifungal Agents
Macrolides
Cycloaddition Reaction
Computer Simulation
Regioselectivity
Conformations
Anti-Bacterial Agents
flavofungin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A synthetic and in silico study on the highly regioselective Diels-Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin. / Fejes, Zsolt; Mándi, Attila; Komáromi, I.; Majoros, László; Batta, G.; Herczegh, P.

In: Tetrahedron Letters, Vol. 51, No. 38, 2010, p. 4968-4971.

Research output: Contribution to journalArticle

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