A study on the amount of high-mobility-group chromatin proteins in T-cells at different stages of differentiation

Valya R. Russanova, I. Andó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The amounts of high-mobility-group proteins (HMG) 1 and 2 in different mouse T-cell populations are studied. It is shown that the quantity of HMG 1 and 2 is different in functionally distinct T-cells. The level of these proteins in thymus cells is higher than in cortisone-resistant thymocytes and peripheral T-cells; it increases in the cytotoxic cells generated in mixed lymphocyte culture. The quantity of HMG is negligible in memory T-cells and increases when the latter cells are stimulated again. The differences found in the levels of HMG 1 and 2 could be related to the rate of cell proliferation and to the changes in chromatin structure at each functional stage of differentiating T-cells.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalBBA - Gene Structure and Expression
Volume825
Issue number4
DOIs
Publication statusPublished - Aug 21 1985

Fingerprint

High Mobility Group Proteins
T-cells
Chromatin
T-Lymphocytes
Proteins
Thymus
Lymphocytes
Cortisone
Cell proliferation
Thymocytes
Cell culture
Thymus Gland
Cell Proliferation
Data storage equipment
Population

Keywords

  • (T-lymphocytes)
  • Cell differentiation
  • Chromatin
  • High-mobility-group protein

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Genetics
  • Structural Biology

Cite this

A study on the amount of high-mobility-group chromatin proteins in T-cells at different stages of differentiation. / Russanova, Valya R.; Andó, I.

In: BBA - Gene Structure and Expression, Vol. 825, No. 4, 21.08.1985, p. 405-410.

Research output: Contribution to journalArticle

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