A study of hyperlipidaemia induced by ascites tumours

T. Kremmer, L. Holczinger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In mice four stages of hyperlipidemia induced by Ehrlich ascites tumour could be distinguished. Hyperlipidemia is characterized mainly by increased serum VLDL content accompanied by high triglyceride concentration. The only exception was the regressive stage III where the serum lipid level (VLDL) has temporarily decreased. From the results obtained with the simultaneous examination of the liver, mesenteric fat tissue, tumor cell and ascites plasma lipids, it may be concluded that the endogeneous fat mobilization induced by tumour cells via increased VLDL synthesis and secretion of liver will lead to hyperlipidaemia and to the total depletion of the lipid stores. Rapid and reversible fall in lipid level following the withdrawal of ascites fluid in tumorous animals demonstrated clearly the direct effect of the tumour cells on lipid-lipoprotein metabolism of the host organism.

Original languageEnglish
Pages (from-to)369-379
Number of pages11
JournalActa morphologica Academiae Scientiarum Hungaricae
Volume24
Issue number4
Publication statusPublished - Dec 1 1976

ASJC Scopus subject areas

  • Anatomy

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