A study of β-cyclodextrin inclusion complexes with progesterone and hydrocortisone using rotating frame Overhauser spectroscopy

P. Forgó, G. Göndös

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Inclusion complexes of β-cyclodextrin with two steroid derivatives, progesterone (pregn-4-ene-3,20-dione) and hydrocortisone (11,17,21-trihydroxy-pregn-4-ene-3,20-dione), were studied in the liquid state by NMR spectroscopy. The complex formation process was monitored by intermolecular dipolar interactions between 1H signals in the hydrophobic β-cyclodextrin cavity (H-3 and H-5 of the α-glucose units) and the steroid moiety in ROESY spectra. The data revealed that progesterone is fully immersed in the β-cyclodextrin cavity; however, complete inclusion of the hydrocortisone molecule was prevented by the polar hydroxyl groups on its surface.

Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalMonatshefte fur Chemie
Volume133
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Cyclodextrins
Progesterone
Hydrocortisone
Spectroscopy
Steroids
Hydroxyl Radical
Nuclear magnetic resonance spectroscopy
Derivatives
Glucose
Molecules
Liquids

Keywords

  • Cyclodextrin
  • Inclusion complexes
  • NMR spectroscopy
  • ROESY
  • Steroids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A study of β-cyclodextrin inclusion complexes with progesterone and hydrocortisone using rotating frame Overhauser spectroscopy. / Forgó, P.; Göndös, G.

In: Monatshefte fur Chemie, Vol. 133, No. 1, 2002, p. 101-106.

Research output: Contribution to journalArticle

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