A softening laminar electrode for recording single unit activity from the rat hippocampus

A. Zátonyi, G. Orbán, R. Modi, G. Márton, D. Meszéna, I. Ulbert, A. Pongrácz, M. Ecker, W. E. Voit, A. Joshi-Imre, Z. Fekete

Research output: Contribution to journalArticle

Abstract

Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demonstrate the viability of this material engineering approach. In our paper, we present a robust technology of softening neural microelectrode and demonstrate its recording performance in the hippocampus of rat subjects. The 5 mm long, single shank, multi-channel probes are composed of a custom thiol-ene/acrylate thermoset polymer substrate, and were micromachined by standard MEMS processes. A special packaging technique is also developed, which guarantees the stable functionality and longevity of the device, which were tested under in vitro conditions prior to animal studies. The 60 micron thick device was successfully implanted to 4.5 mm deep in the hippocampus without the aid of any insertion shuttle. Spike amplitudes of 84 µV peak-to-peak and signal-to-noise ratio of 6.24 were achieved in acute experiments. Our study demonstrates that softening neural probes may be used to investigate deep layers of the rat brain.

Original languageEnglish
Article number2321
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Hippocampus
Electrodes
Micro-Electrical-Mechanical Systems
Equipment and Supplies
Elastic Modulus
Brain
Signal-To-Noise Ratio
Microelectrodes
Product Packaging
Sulfhydryl Compounds
Polymers
Technology
In Vitro Techniques
acrylic acid

ASJC Scopus subject areas

  • General

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A softening laminar electrode for recording single unit activity from the rat hippocampus. / Zátonyi, A.; Orbán, G.; Modi, R.; Márton, G.; Meszéna, D.; Ulbert, I.; Pongrácz, A.; Ecker, M.; Voit, W. E.; Joshi-Imre, A.; Fekete, Z.

In: Scientific reports, Vol. 9, No. 1, 2321, 01.12.2019.

Research output: Contribution to journalArticle

Zátonyi, A, Orbán, G, Modi, R, Márton, G, Meszéna, D, Ulbert, I, Pongrácz, A, Ecker, M, Voit, WE, Joshi-Imre, A & Fekete, Z 2019, 'A softening laminar electrode for recording single unit activity from the rat hippocampus' Scientific reports, vol. 9, no. 1, 2321. https://doi.org/10.1038/s41598-019-39835-6
Zátonyi, A. ; Orbán, G. ; Modi, R. ; Márton, G. ; Meszéna, D. ; Ulbert, I. ; Pongrácz, A. ; Ecker, M. ; Voit, W. E. ; Joshi-Imre, A. ; Fekete, Z. / A softening laminar electrode for recording single unit activity from the rat hippocampus. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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