A simple reaction kinetic model of rapid (G protein dependent) and slow (β-Arrestin dependent) transmission

Dávid Csercsik, K. Hangos, György M. Nagy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this paper the qualitative dynamic behavior of reaction kinetic models of G protein signaling is examined. A simplified basic G protein signaling structure is defined, which is extended to be able to take the effect of slow transmission, RGS mediated feedback regulation and ERK-phosphatase mediated feedback regulation into account. The resulting model gives rise to an acceptable qualitative approximation of the G protein dependent and independent ERK activation dynamics that is in good agreement with the experimentally observed behavior.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalJournal of Theoretical Biology
Volume255
Issue number1
DOIs
Publication statusPublished - Nov 7 2008

Fingerprint

arrestins
Arrestin
G Protein
Reaction Kinetics
reaction kinetics
Kinetic Model
G-proteins
GTP-Binding Proteins
Reaction kinetics
Proteins
Dependent
Feedback
Qualitative Behavior
Phosphatases
Phosphoric Monoester Hydrolases
Dynamic Behavior
Activation
Chemical activation
Approximation
Model

Keywords

  • G protein signaling
  • MAPK/ERK
  • Reaction kinetic systems
  • Regulators of G protein signaling
  • Slow transmission

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Modelling and Simulation
  • Statistics and Probability
  • Applied Mathematics

Cite this

A simple reaction kinetic model of rapid (G protein dependent) and slow (β-Arrestin dependent) transmission. / Csercsik, Dávid; Hangos, K.; Nagy, György M.

In: Journal of Theoretical Biology, Vol. 255, No. 1, 07.11.2008, p. 119-128.

Research output: Contribution to journalArticle

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