A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC-MS with liquid-liquid extraction

L. Institóris, Vilmos Angyal, Zsófia Árok, Éva Kereszty, Tibor Varga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The analytical system used for determination of 22 illicit and licit drugs by gas chromatography-mass spectrometry following liquid-liquid extraction has been extended with an additional extraction step with n-butyl acetate:CH 2Cl 2 = 1:8 to determine benzoylecgonine from the same oral fluid, blood, or urine samples. The extraction recovery of benzoylecgonine was 39.7% for oral fluid, 14.9% for blood, and 26.7% for urine; the cutoffs were 25, 8.0, and 8.0 ng/ml, respectively. The method was fully validated and proved suitable in further proficiency tests and for analysis of 2738 oral fluid, 197 blood, and 1298 urine samples.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalForensic Toxicology
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Liquid-Liquid Extraction
Street Drugs
Blood
Urine
Fluids
Liquids
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Recovery
benzoylecgonine

Keywords

  • Benzoylecgonine
  • Blood
  • GC-MS
  • Liquid-liquid extraction
  • Oral fluid
  • Urine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Biochemistry, medical

Cite this

A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC-MS with liquid-liquid extraction. / Institóris, L.; Angyal, Vilmos; Árok, Zsófia; Kereszty, Éva; Varga, Tibor.

In: Forensic Toxicology, Vol. 30, No. 1, 01.2012, p. 59-65.

Research output: Contribution to journalArticle

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