An improved annulation sequence is presented, making use of the one-pot cyclization of 5-nitropentan-2-one and cyclopent-2-enone diesters to afford 7-methyl-4-nitro-1-oxohydrindene derivatives. Functional group elaborations of these intermediates lead to a series of the title compounds, which could be readily converted to the tricyclic moieties of strigol and its analogues of biological importance.
- Cyclopent-2-enone derivatives
- Michael reaction
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry