A simple method for the preparation of various 1-oxo-hydrindene-2-acetic and -propionic acids. Valuable precursors of strigol and its analogues

István Kádas, Géza Árvai, L. Tőke, Gábor Tóth, A. Szöllösy, Mária Bihari

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

An improved annulation sequence is presented, making use of the one-pot cyclization of 5-nitropentan-2-one and cyclopent-2-enone diesters to afford 7-methyl-4-nitro-1-oxohydrindene derivatives. Functional group elaborations of these intermediates lead to a series of the title compounds, which could be readily converted to the tricyclic moieties of strigol and its analogues of biological importance.

Original languageEnglish
Pages (from-to)2895-2906
Number of pages12
JournalTetrahedron
Volume50
Issue number9
DOIs
Publication statusPublished - Feb 28 1994

Fingerprint

Cyclization
Propionates
Acetic Acid
Functional groups
Derivatives
cyclodrine
strigol

Keywords

  • 5-Nitropentan-2-one
  • Annulation
  • Cyclopent-2-enone derivatives
  • Michael reaction
  • Strigol

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A simple method for the preparation of various 1-oxo-hydrindene-2-acetic and -propionic acids. Valuable precursors of strigol and its analogues. / Kádas, István; Árvai, Géza; Tőke, L.; Tóth, Gábor; Szöllösy, A.; Bihari, Mária.

In: Tetrahedron, Vol. 50, No. 9, 28.02.1994, p. 2895-2906.

Research output: Contribution to journalArticle

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AU - Kádas, István

AU - Árvai, Géza

AU - Tőke, L.

AU - Tóth, Gábor

AU - Szöllösy, A.

AU - Bihari, Mária

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