A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N-Benzylpiperidinone in Water

Ferenc Miklõs, F. Fülöp

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6 Citations (Scopus)

Abstract

An environmentally benign condensation of anthranilic hydrazide with cyclohexanone or N-benzylpiperidin-4-one in aqueous medium has been developed for the synthesis of benzoylhydrazones A. The thermal rearrangements of hydrazones A yielded 3′-aminospiro-quinazolinones B. When A or B was reacted repeatedly with cyclohexanone or N-benzylpiperidin-4-one, spiroquinazoline-hydrazones C were formed. From aqueous suspensions, products could be isolated in high purity by simple filtration.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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ASJC Scopus subject areas

  • Organic Chemistry

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