A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N-Benzylpiperidinone in Water

Ferenc Miklõs, F. Fülöp

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An environmentally benign condensation of anthranilic hydrazide with cyclohexanone or N-benzylpiperidin-4-one in aqueous medium has been developed for the synthesis of benzoylhydrazones A. The thermal rearrangements of hydrazones A yielded 3′-aminospiro-quinazolinones B. When A or B was reacted repeatedly with cyclohexanone or N-benzylpiperidin-4-one, spiroquinazoline-hydrazones C were formed. From aqueous suspensions, products could be isolated in high purity by simple filtration.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Hydrazones
Condensation
Quinazolinones
Water
Suspensions
cyclohexanone
spiroquinazoline
Hot Temperature

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A Simple Green Protocol for the Condensation of Anthranilic Hydrazide with Cyclohexanone and N-Benzylpiperidinone in Water. / Miklõs, Ferenc; Fülöp, F.

In: Journal of Heterocyclic Chemistry, Vol. 53, No. 1, 01.01.2016, p. 32-37.

Research output: Contribution to journalArticle

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