A simple efficient synthesis of a new, versatile tetrahydro-isoquinoline-1,3-aminoalcohol synthon1,2

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Abstract

Through the addition of 2 moles of formaldehyde to l-methyl-6,7-dimethoxy- and 6,7-diethoxy-3,4-dihydroisoquinoline, the corresponding 1-[bis(hydroxymethyl)methyl]-6,7-dialkoxy-3,4-dihydroisoquinolines (3a,b) were prepared, which were then reduced to the 1,3,3′-trifunctional tetrahydroisoquinoline aminoalcohol synthons (5a,b).

Original languageEnglish
Pages (from-to)2227-2231
Number of pages5
JournalHeterocycles
Volume24
Issue number8
Publication statusPublished - Aug 1 1986

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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