A simple, efficient, and selective deuteration via a flow chemistry approach

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16 Citations (Scopus)

Abstract

A simple and efficient deuteration methodology has been established for a wide variety of substrates using a continuous flow hydrogenation reactor. The described procedure is many times faster (1 mg min-1) compared to literature methods and the purity of the crude product can be as high as 99%. The deuterium source is D2O, the consumption of which is very low.

Original languageEnglish
Pages (from-to)4372-4374
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number30
DOIs
Publication statusPublished - Jul 29 2009

Keywords

  • Deuteration
  • Flow chemistry
  • Heterogenous catalysis
  • Palladium
  • Reduction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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