A simple chromatographic route for the isolation of meso diaminopimelic acid

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Abstract

Meso diaminopimelic acid is an important noncoded amino acid found in Gram-negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pure meso diaminopimelic acid via an high-performance liquid chromatography separation. In our new approach, the underivatized three isomers of diaminopimelic acid were separated on a crown ether-based chiral stationary phase. For the structure identification, 1H NMR spectroscopy was applied.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalChirality
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 1 2011

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Keywords

  • (+)-(18-crown-6)-2,3, 11,12-tetracarboxylic acid-based stationary phase
  • HPLC
  • NMR structure
  • chiral chromatography
  • meso diaminopimelic acid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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