A short, enantiospecific synthesis of a protected seco acid precursor to (R,R)-(-) pyrenophorin

Robert V. Hoffman, Tamas Patonay, Naresh K. Nayyar, Junhua Tao

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Abstract

Described herein is a four-step enantiospecific synthesis of a protected seco acid precursor of (R,R)-(-)-pyrenophorin in 23% yield from a chiral β-ketoester 3, which can be prepared in one step from ethyl acetoacetate by a standard procedure.

Original languageEnglish
Pages (from-to)2381-2384
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number14
DOIs
Publication statusPublished - Apr 1 1996

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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