A short and facile synthetic route to prenylated flavones. Cyclodehydrogenation of prenylated 2'-hydroxychalcones by a hypervalent iodine reagent

Katalin Gulácsi, György Litkei, Sándor Antus, Tamás E. Gunda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The first synthesis of the prenylated flavones kanzonol-D (1), -E (3) and yinyanghuo-C (4) was accomplished by cyclodehydrogenation of the appropriately substituted 2'-hydroxychalcones 16, 14 and 11, respectively, in presence of phenyl-iodine(III) diacetate (PIDA)/potassium hydroxide in methanol. The synthesis of kanzonol-B (13) was also achieved from the 2'- hydroxychalcone 12.

Original languageEnglish
Pages (from-to)13867-13876
Number of pages10
JournalTetrahedron
Volume54
Issue number45
DOIs
Publication statusPublished - Nov 5 1998

Fingerprint

Flavones
Iodine
Methanol
2'-hydroxychalcone
potassium hydroxide

Keywords

  • Chalcones
  • Flavones
  • Flavonoids
  • Hypervalent iodine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A short and facile synthetic route to prenylated flavones. Cyclodehydrogenation of prenylated 2'-hydroxychalcones by a hypervalent iodine reagent. / Gulácsi, Katalin; Litkei, György; Antus, Sándor; Gunda, Tamás E.

In: Tetrahedron, Vol. 54, No. 45, 05.11.1998, p. 13867-13876.

Research output: Contribution to journalArticle

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