A selective inversion recovery method for the improvement of 23Na NMR spectral resolution in isolated perfused rat hearts.

T. Símor, S. K. Kim, W. J. Chu, G. M. Pohost, G. A. Elgavish

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Shift-reagent-aided 23Na NMR spectroscopy allows differentiation of the intracellular (Na(i)) and extracellular sodium (Na(o)) signals. The goal of the present study has been to develop a 23Na NMR spectroscopic method to minimize the intensity of the shift-reagent-shifted Na(o) signal and thus increase Na(i) resolution. This is achieved by a selective inversion recovery (SIR) method which enhances the resolution between the Na(i) and Na(o) peaks in shift-reagent-aided 23Na NMR spectroscopy. The application of SIR with Dy(TTHA), Tm(DOTP), or with low concentrations of Dy(PPP)2 results in both good spectral resolution and physiologically acceptable contractile function in the isolated, perfused rat heart model.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalNMR in Biomedicine
Volume6
Issue number3
Publication statusPublished - May 1993

Fingerprint

Spectral resolution
Rats
Nuclear magnetic resonance
Recovery
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Sodium

ASJC Scopus subject areas

  • Biophysics
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

A selective inversion recovery method for the improvement of 23Na NMR spectral resolution in isolated perfused rat hearts. / Símor, T.; Kim, S. K.; Chu, W. J.; Pohost, G. M.; Elgavish, G. A.

In: NMR in Biomedicine, Vol. 6, No. 3, 05.1993, p. 201-208.

Research output: Contribution to journalArticle

Símor, T. ; Kim, S. K. ; Chu, W. J. ; Pohost, G. M. ; Elgavish, G. A. / A selective inversion recovery method for the improvement of 23Na NMR spectral resolution in isolated perfused rat hearts. In: NMR in Biomedicine. 1993 ; Vol. 6, No. 3. pp. 201-208.
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