A role of adhesion molecules in neuroglial plasticity

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Glial cells are exquisitely sensitive to changes in neuronal activity, and their capacity for structural plasticity including migration is critical for remodeling an repair of nervous tissue. Our in vitro studies suggest that isoforms of the neural cell adhesion molecule (NCAM) carrying an unconventional carbohydrate polymer, polysialic acid (PSA), are involved in these events. We have demonstrated that neurohypophyseal explants from newborn rats generate cellular outgrowth of immature astrocytes displaying the characteristics of oligodendrocyte-type 2 astrocyte (O-2A) progenitor cells previously identified in the optic nerve. Treatment of O-2A cells with the enzyme Endo N, which specifically removes PSA from the cells surface, produced a complete blockade of the dispersion of the O-2A cell population from the explant. Identical effects of Endo N were observed in migration assays using cortical O-2A cells. Neurohypophyseal O-2A cells express functional NMDA class of glutamate receptors and the pharmacological blockade of these receptors inhibit PSA-NCAM biosynthesis and dramatically diminish O-2A cell migration from neurohypophyseal explants. This suggests a potential mechanism through which neuronal activity via glutamate release may regulate PSA-NCAM expression on immature glial cells, which in turn is critical for their migration.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume140
Issue number1-2
DOIs
Publication statusPublished - May 25 1998

Fingerprint

Astrocytes
Oligodendroglia
Plasticity
Adhesion
Molecules
Neural Cell Adhesion Molecules
Neuroglia
Nerve Tissue
Biosynthesis
Glutamate Receptors
N-Methylaspartate
Optic Nerve
Cell Movement
Rats
Glutamic Acid
Assays
Optics
Polymers
Protein Isoforms
Repair

Keywords

  • Neural cell adhesion molecule
  • Plasticity
  • Polysialic acid

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

A role of adhesion molecules in neuroglial plasticity. / Kiss, J.

In: Molecular and Cellular Endocrinology, Vol. 140, No. 1-2, 25.05.1998, p. 89-94.

Research output: Contribution to journalArticle

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