A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia

Nandor Gabor Than, Roberto Romero, Offer Erez, Juan Pedro Kusanovic, Adi L. Tarca, Samuel S. Edwin, Jung Sun Kim, Sonia S. Hassan, Jimmy Espinoza, Pooja Mittal, Shali Mazaki-tovi, Lara Friel, Francesca Gotsch, Edi Vaisbuch, Natalia Camacho, Z. Papp

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Problem: Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia. Method of study: This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. Results: Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with pre-eclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02). Conclusion: The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.

Original languageEnglish
Pages (from-to)333-345
Number of pages13
JournalAmerican Journal of Reproductive Immunology
Volume60
Issue number4
DOIs
Publication statusPublished - 2008

Fingerprint

Mannose-Binding Lectin
Pre-Eclampsia
Immune System
Pregnant Women
Mothers
Pattern Recognition Receptors
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Alleles
Inflammation
Pregnancy
Serum

Keywords

  • Maternal systemic inflammation
  • MBL genotypes
  • Pattern-recognition receptor
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia. / Than, Nandor Gabor; Romero, Roberto; Erez, Offer; Kusanovic, Juan Pedro; Tarca, Adi L.; Edwin, Samuel S.; Kim, Jung Sun; Hassan, Sonia S.; Espinoza, Jimmy; Mittal, Pooja; Mazaki-tovi, Shali; Friel, Lara; Gotsch, Francesca; Vaisbuch, Edi; Camacho, Natalia; Papp, Z.

In: American Journal of Reproductive Immunology, Vol. 60, No. 4, 2008, p. 333-345.

Research output: Contribution to journalArticle

Than, NG, Romero, R, Erez, O, Kusanovic, JP, Tarca, AL, Edwin, SS, Kim, JS, Hassan, SS, Espinoza, J, Mittal, P, Mazaki-tovi, S, Friel, L, Gotsch, F, Vaisbuch, E, Camacho, N & Papp, Z 2008, 'A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia', American Journal of Reproductive Immunology, vol. 60, no. 4, pp. 333-345. https://doi.org/10.1111/j.1600-0897.2008.00631.x
Than, Nandor Gabor ; Romero, Roberto ; Erez, Offer ; Kusanovic, Juan Pedro ; Tarca, Adi L. ; Edwin, Samuel S. ; Kim, Jung Sun ; Hassan, Sonia S. ; Espinoza, Jimmy ; Mittal, Pooja ; Mazaki-tovi, Shali ; Friel, Lara ; Gotsch, Francesca ; Vaisbuch, Edi ; Camacho, Natalia ; Papp, Z. / A role for mannose-binding lectin, a component of the innate immune system in pre-eclampsia. In: American Journal of Reproductive Immunology. 2008 ; Vol. 60, No. 4. pp. 333-345.
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abstract = "Problem: Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia. Method of study: This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. Results: Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with pre-eclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02). Conclusion: The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.",
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AU - Than, Nandor Gabor

AU - Romero, Roberto

AU - Erez, Offer

AU - Kusanovic, Juan Pedro

AU - Tarca, Adi L.

AU - Edwin, Samuel S.

AU - Kim, Jung Sun

AU - Hassan, Sonia S.

AU - Espinoza, Jimmy

AU - Mittal, Pooja

AU - Mazaki-tovi, Shali

AU - Friel, Lara

AU - Gotsch, Francesca

AU - Vaisbuch, Edi

AU - Camacho, Natalia

AU - Papp, Z.

PY - 2008

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N2 - Problem: Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia. Method of study: This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. Results: Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with pre-eclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02). Conclusion: The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.

AB - Problem: Mannose-binding lectin (MBL) is a pattern-recognition receptor that activates complement and modulates inflammation. Homozygosity for the most common allele of the MBL2 gene that is associated with high MBL serum concentrations is more prevalent among patients with pre-eclampsia. The objective of this study was to determine maternal plasma MBL concentrations in normal pregnant women and patients with pre-eclampsia. Method of study: This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. Results: Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with pre-eclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02). Conclusion: The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.

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KW - Single nucleotide polymorphism

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