A ribonucleotide reductase gene is a transcriptional target of p53 and p73

K. Nakano, E. Bálint, M. Ashcroft, K. H. Vousden

Research output: Contribution to journalArticle

190 Citations (Scopus)

Abstract

Many p53-inducible genes have been identified that might play a role in mediating the various downstream activities of p53. We have identified a close relative of ribonucleotide reductase, recently named p53R2, as a p53-inducible gene, and show that this gene is activated by several stress signals that activate a p53 response, including DNA damaging agents and p14(ARF). p53R2 expression was induced by p53 mutants that are defective for the activation of apoptosis, but retain cell cycle arrest function, although no induction of p53R2 was seen in response to p21(WAF1/CIP1)-mediated cell cycle arrest. Several isoforms of the p53 family member p73 were also shown to induce p53R2 expression. Transient ectopic expression of either wild type p53R2 or p53R2 targeted to the nucleus, did not significantly alter cell cycle progression in unstressed cells. The identification of this gene as a p53 target supports a direct role for p53 in DNA repair, in addition to inhibition of growth of damaged cells.

Original languageEnglish
Pages (from-to)4283-4289
Number of pages7
JournalOncogene
Volume19
Issue number37
Publication statusPublished - Aug 31 2000

Fingerprint

Ribonucleotide Reductases
p53 Genes
Cell Cycle Checkpoints
Tumor Suppressor Protein p14ARF
DNA Repair
Genes
Cell Cycle
Protein Isoforms
Apoptosis
DNA
Growth
Ectopic Gene Expression
Inhibition (Psychology)

Keywords

  • DNA damage
  • p53
  • p53R2
  • p73
  • Ribonucleotide reductase

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Nakano, K., Bálint, E., Ashcroft, M., & Vousden, K. H. (2000). A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene, 19(37), 4283-4289.

A ribonucleotide reductase gene is a transcriptional target of p53 and p73. / Nakano, K.; Bálint, E.; Ashcroft, M.; Vousden, K. H.

In: Oncogene, Vol. 19, No. 37, 31.08.2000, p. 4283-4289.

Research output: Contribution to journalArticle

Nakano, K, Bálint, E, Ashcroft, M & Vousden, KH 2000, 'A ribonucleotide reductase gene is a transcriptional target of p53 and p73', Oncogene, vol. 19, no. 37, pp. 4283-4289.
Nakano K, Bálint E, Ashcroft M, Vousden KH. A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene. 2000 Aug 31;19(37):4283-4289.
Nakano, K. ; Bálint, E. ; Ashcroft, M. ; Vousden, K. H. / A ribonucleotide reductase gene is a transcriptional target of p53 and p73. In: Oncogene. 2000 ; Vol. 19, No. 37. pp. 4283-4289.
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