Using the reverse radial immunodiffusion method and the IgE test, the authors carried out quantitative serum protein estimations (IgG, IgA, IgM, IgD, IgE, beta 1A transferrin, hemopexin, coeruloplasmin, albumin, prealbumin) in 14 patients with manifested allergic contact dermatitis and in 24 patients with what was evidently a contact dermatitis from drugs. In both groups a characteristic dysproteinemia could be determined. In the allergic contact dermatitis the IgM was raised (p<0.02), and so were the beta 1A globulin (p<0.001), the transferrin (p<0.01) and the coeruloplasmin (p<0.001) while the albumin (p<0.01) and the prealbumin (p<0.01) were lowered. In the patients with drug allergy there was an increase of beta 1A globulin (p<0.05) and hemopexin (p<0.01) while the prealbumin (p<0.001) and albumin (p<0.02) were diminished. Of all these anomalies the authors consider - in connection with previous investigations in both groups of diseases - the very significant prealbumin diminution as the most characteristic. The possible causes of this diminution are mentioned; as the most probable among them they consider to be those mechanisms in which prealbumin functions as hapten carrier.
|Translated title of the contribution||A reverse radial immunodiffusion method for quantitative determination of serum proteins in allergic contact dermatitis and drug allergies|
|Number of pages||10|
|Journal||H+G Zeitschrift fur Hautkrankheiten|
|Publication status||Published - Jan 1 1976|
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