A recent perspective on alcohol, immunity, and host defense

G. Szabó, Pranoti Mandrekar

Research output: Contribution to journalReview article

238 Citations (Scopus)

Abstract

Background: Multiple line of clinical and experimental evidence demonstrates that both acute, moderate, and chronic, excessive alcohol use result in various abnormalities in the functions of the immune system. Methods: Medline and Pubmed databases were used to identify published reports with particular interest in the period of 2000-2008 in the subject of alcohol use, infection, inflammation, innate, and adaptive immunity. Results: This review article summarizes recent findings relevant to acute or chronic alcohol use-induced immunomodulation and its consequences on host defense against microbial pathogens and tissue injury. Studies with in vivo and in vitro alcohol administration are both discussed. The effects of alcohol on lung infections, trauma and burn injury, liver, pancreas, and cardiovascular diseases are evaluated with respect to the role of immune cells. Specific changes in innate immune response and abnormalities in adaptive immunity caused by alcohol intake are detailed. Conclusion: Altered inflammatory cell and adaptive immune responses after alcohol consumption result in increased incidence and poor outcome of infections and other organ-specific immune-mediated effects.

Original languageEnglish
Pages (from-to)220-232
Number of pages13
JournalAlcoholism: Clinical and Experimental Research
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Immunity
Alcohols
Adaptive Immunity
Innate Immunity
Wounds and Injuries
Infection
Immunomodulation
Immune system
PubMed
Alcohol Drinking
Pathogens
Liver Diseases
Pancreas
Immune System
Liver
Cardiovascular Diseases
Databases
Inflammation
Lung
Tissue

Keywords

  • Inflammation
  • Innate and adaptive immunity
  • Macrophages
  • T cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology

Cite this

A recent perspective on alcohol, immunity, and host defense. / Szabó, G.; Mandrekar, Pranoti.

In: Alcoholism: Clinical and Experimental Research, Vol. 33, No. 2, 02.2009, p. 220-232.

Research output: Contribution to journalReview article

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