A recent aetiological study on facial clefting in Hungary.

E. Czeizel, E. Nagy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A case-control epidemiological and family study was organized of 2024 index patients born between 1970 and 1976 affected by isolated cleft lip +/- cleft palate, isolated posterior cleft palate and multiple congenital abnormalities including facial clefting and of their matched control cases. The specific rate of affected parents and sibs was 2.4% and 4.2% in the isolated cleft lip +/- cleft palate sample, while 2.2% and 3.2% in the isolated posterior cleft palate group. The proportion of polygenic liability was about 77 +/- 8% in isolated cleft lip +/- cleft palate cases. Among teratogens, the triggering impact of certain anticonvulsants was confirmed.

Original languageEnglish
Pages (from-to)145-166
Number of pages22
JournalActa Paediatrica Hungarica
Volume27
Issue number2
Publication statusPublished - 1986

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Hungary
Cleft Palate
Cleft Lip
Multiple Abnormalities
Teratogens
Anticonvulsants
Epidemiologic Studies
Parents

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A recent aetiological study on facial clefting in Hungary. / Czeizel, E.; Nagy, E.

In: Acta Paediatrica Hungarica, Vol. 27, No. 2, 1986, p. 145-166.

Research output: Contribution to journalArticle

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