A rational approach for generating cardiac troponin i selective Spiegelmers

Zsuzsanna Szeitner, Gergely Lautner, Szilvia K. Nagy, R. Gyurcsányi, T. Mészáros

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum. This journal is

Original languageEnglish
Pages (from-to)6801-6804
Number of pages4
JournalChemical Communications
Volume50
Issue number51
DOIs
Publication statusPublished - Jun 28 2014

Fingerprint

Epitopes
Troponin
Troponin I
Screening
Proteins
Serum

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys
  • Medicine(all)

Cite this

A rational approach for generating cardiac troponin i selective Spiegelmers. / Szeitner, Zsuzsanna; Lautner, Gergely; Nagy, Szilvia K.; Gyurcsányi, R.; Mészáros, T.

In: Chemical Communications, Vol. 50, No. 51, 28.06.2014, p. 6801-6804.

Research output: Contribution to journalArticle

Szeitner, Zsuzsanna ; Lautner, Gergely ; Nagy, Szilvia K. ; Gyurcsányi, R. ; Mészáros, T. / A rational approach for generating cardiac troponin i selective Spiegelmers. In: Chemical Communications. 2014 ; Vol. 50, No. 51. pp. 6801-6804.
@article{5bcee14efb354e84a7f94b080699f65c,
title = "A rational approach for generating cardiac troponin i selective Spiegelmers",
abstract = "We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum. This journal is",
author = "Zsuzsanna Szeitner and Gergely Lautner and Nagy, {Szilvia K.} and R. Gyurcs{\'a}nyi and T. M{\'e}sz{\'a}ros",
year = "2014",
month = "6",
day = "28",
doi = "10.1039/c4cc00447g",
language = "English",
volume = "50",
pages = "6801--6804",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "51",

}

TY - JOUR

T1 - A rational approach for generating cardiac troponin i selective Spiegelmers

AU - Szeitner, Zsuzsanna

AU - Lautner, Gergely

AU - Nagy, Szilvia K.

AU - Gyurcsányi, R.

AU - Mészáros, T.

PY - 2014/6/28

Y1 - 2014/6/28

N2 - We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum. This journal is

AB - We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84901795650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901795650&partnerID=8YFLogxK

U2 - 10.1039/c4cc00447g

DO - 10.1039/c4cc00447g

M3 - Article

C2 - 24836380

AN - SCOPUS:84901795650

VL - 50

SP - 6801

EP - 6804

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 51

ER -