A rational approach for generating cardiac troponin I selective spiegelmers

Zsuzsanna Szeitner, Gergely Lautner, Szilvia K. Nagy, Róbert E. Gyurcsányi, Tamás Mészáros

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.

Original languageEnglish
Pages (from-to)6801-6804
Number of pages4
JournalChemical Communications
Volume50
Issue number51
DOIs
Publication statusPublished - May 29 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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