A cyanosis ritka oka

Sulphhaemoglobinaemia

Translated title of the contribution: A rare cause of cyanosis - A case report on sulfhemoglobinemia

M. Harangi, J. Mátyus, Erzsébet Nagy, E. Nagy, G. Paragh, J. Balla, V. Anna Olah

Research output: Contribution to journalArticle

Abstract

INTRODUCTION - Sulfhemoglobinemia (SHb) is an uncommon cause of cyanosis that is predominantly caused by drugs in adults. CLINICAL CASE - We report on an unusual case of sodium sulfate induced sulfhemoglobinemia in a 61-year-old woman after surgical polypectomy. Fractional hemoglobin derivates were assayed by spectrophotometry and high-performance liquid chromatography (HPLC). The sulfhemoglobinemia ratio was 8.6% in the first sample, and 3.77% a month later measured by spectrophotometry. In the hemolysate a new peak was identified as sulfhemoglobinemia by HPLC. It showed the presence of 9.37% sulfhemoglobinemia in the first sample and 4.88% a month later. After omitting the suspected toxic agent the cyanosis decreased significantly. CONCLUSIONS - The findings underline the importance of routine sulfhemoglobinemia analysis in cases of cyanosis of unknown origin.

Original languageHungarian
Pages (from-to)52-55
Number of pages4
JournalLege Artis Medicinae
Volume16
Issue number1
Publication statusPublished - Jan 2006

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Sulfhemoglobinemia
Cyanosis
Spectrophotometry
High Pressure Liquid Chromatography
Poisons
Hemoglobins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A cyanosis ritka oka : Sulphhaemoglobinaemia. / Harangi, M.; Mátyus, J.; Nagy, Erzsébet; Nagy, E.; Paragh, G.; Balla, J.; Olah, V. Anna.

In: Lege Artis Medicinae, Vol. 16, No. 1, 01.2006, p. 52-55.

Research output: Contribution to journalArticle

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T2 - Sulphhaemoglobinaemia

AU - Harangi, M.

AU - Mátyus, J.

AU - Nagy, Erzsébet

AU - Nagy, E.

AU - Paragh, G.

AU - Balla, J.

AU - Olah, V. Anna

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N2 - INTRODUCTION - Sulfhemoglobinemia (SHb) is an uncommon cause of cyanosis that is predominantly caused by drugs in adults. CLINICAL CASE - We report on an unusual case of sodium sulfate induced sulfhemoglobinemia in a 61-year-old woman after surgical polypectomy. Fractional hemoglobin derivates were assayed by spectrophotometry and high-performance liquid chromatography (HPLC). The sulfhemoglobinemia ratio was 8.6% in the first sample, and 3.77% a month later measured by spectrophotometry. In the hemolysate a new peak was identified as sulfhemoglobinemia by HPLC. It showed the presence of 9.37% sulfhemoglobinemia in the first sample and 4.88% a month later. After omitting the suspected toxic agent the cyanosis decreased significantly. CONCLUSIONS - The findings underline the importance of routine sulfhemoglobinemia analysis in cases of cyanosis of unknown origin.

AB - INTRODUCTION - Sulfhemoglobinemia (SHb) is an uncommon cause of cyanosis that is predominantly caused by drugs in adults. CLINICAL CASE - We report on an unusual case of sodium sulfate induced sulfhemoglobinemia in a 61-year-old woman after surgical polypectomy. Fractional hemoglobin derivates were assayed by spectrophotometry and high-performance liquid chromatography (HPLC). The sulfhemoglobinemia ratio was 8.6% in the first sample, and 3.77% a month later measured by spectrophotometry. In the hemolysate a new peak was identified as sulfhemoglobinemia by HPLC. It showed the presence of 9.37% sulfhemoglobinemia in the first sample and 4.88% a month later. After omitting the suspected toxic agent the cyanosis decreased significantly. CONCLUSIONS - The findings underline the importance of routine sulfhemoglobinemia analysis in cases of cyanosis of unknown origin.

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KW - High-performance liquid chromatography

KW - Sodium sulfate

KW - Spectrophotometry

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