A randomized, controlled trial of a clinical pharmacist intervention in microdiscectomy surgery - Low dose intravenous ketamine as an adjunct to standard therapy

Bushra A. Hadi, Rafat Daas, R. Zelkó

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: The hypothesis that postoperative pain would be reduced by using 1. μg/kg/min of ketamine, both intra- and post-operatively, for lumbar microdiscectomy surgery was assessed by measuring morphine consumption. Patient side effects were reported. Methods: Forty-five patients undergoing microdiscectomy surgery were randomized under double-blind conditions into three groups: Group1 (G1) received normal saline, Group 2 (G2) ketamine (1. μg/kg/min) intra-operatively and Group 3 (G3) ketamine (1. μg/kg/min) both intra- and post-operatively. Morphine consumption, pain scores, nausea and vomiting, CNS disorders were recorded for 24. h post surgery. This study was conducted by applying the concept of a clinical pharmacist intervention. Results: The time for the first analgesia demand dose was significantly shorter (P

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalSaudi Pharmaceutical Journal
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Ketamine
Pharmacists
Randomized Controlled Trials
Morphine
Postoperative Pain
Analgesia
Nausea
Vomiting
Therapeutics
Pain

Keywords

  • Intra-operative
  • Ketamine
  • Microdiscectomy surgery
  • Morphine consumption
  • Nausea and vomiting
  • Post-operative

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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