A quantitative peptide structure vs. retention relationship study

Research output: Contribution to journalArticle

Abstract

The quantitative relationship between the TLC retention parameters of 28 short peptides and their physicochemical characteristics was calculated using linear regression analysis. It was established that surface parameters exert a significant impact on the retention of peptides and the ratio of non-polar surface area/polar surface area exerts the highest influence on the retention. This result maybe due to the fact that peptides turn towards the apolar surface of the stationary phase with their non-polar substructures while the polar molecular parts point into the hydrophilic mobile phase.

Original languageEnglish
Pages (from-to)1057-1059
Number of pages3
JournalJournal of Separation Science
Volume31
Issue number6-7
DOIs
Publication statusPublished - Apr 2008

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Peptides
Linear Models
Regression Analysis
Linear regression
Regression analysis

Keywords

  • Quantitative structure retention relationship
  • Short peptides
  • Thin-layer chromatography

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Chemical Engineering(all)
  • Filtration and Separation

Cite this

A quantitative peptide structure vs. retention relationship study. / Oros, G.; Cserháti, T.

In: Journal of Separation Science, Vol. 31, No. 6-7, 04.2008, p. 1057-1059.

Research output: Contribution to journalArticle

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