A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis

J. Fehér, Ágnes Cornides, Anna Romány, Mihály Kárteszi, László Szalay, Árpád Gógl, José Picazo

Research output: Contribution to journalArticle

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Abstract

A randomized, single-blind controlled multicenter study of insulin and glucagon infusion was carried out in 66 patients with acute alcoholic hepatitis. Thirty-three patients were treated with insulin 10 U and glucagon 1 mg in 500 ml 5% glucose in water via a peripheral vein for 2-6 h three times every day for 3 weeks. Patients in the control group received 5% glucose in an identical fashion. Fourteen control patients and five treated patients died from liver failure during the study (P <0.02). Clinical features of liver disease on entry into the study were similar in the two groups, but the total serum bilirubin, aspartate aminotransferase, gamma-glutamyltranspeptidase activities and prothrombin time significantly improved in the treated patients (P <0.05). Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis.

Original languageEnglish
Pages (from-to)224-231
Number of pages8
JournalJournal of Hepatology
Volume5
Issue number2
DOIs
Publication statusPublished - 1987

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Alcoholic Hepatitis
Glucagon
Multicenter Studies
Prospective Studies
Insulin
Therapeutics
Glucose
Prothrombin Time
Liver Failure
Aspartate Aminotransferases
Bilirubin
Liver Diseases
Veins
Control Groups
Water
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis. / Fehér, J.; Cornides, Ágnes; Romány, Anna; Kárteszi, Mihály; Szalay, László; Gógl, Árpád; Picazo, José.

In: Journal of Hepatology, Vol. 5, No. 2, 1987, p. 224-231.

Research output: Contribution to journalArticle

Fehér, J. ; Cornides, Ágnes ; Romány, Anna ; Kárteszi, Mihály ; Szalay, László ; Gógl, Árpád ; Picazo, José. / A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis. In: Journal of Hepatology. 1987 ; Vol. 5, No. 2. pp. 224-231.
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