A progesterone-induced blocking factor corrects high resorption rates in mice treated with antiprogesterone

J. Szekeres-Barthó, G. Chaouat, R. Kinsky

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Earlier we showed that because of the presence of functional progesterone receptors, lymphocytes of healthy pregnant women produced an immunomodulatory protein in the presence of progesterone, whereas those of nonpregnant persons did not. Progesterone-treated murine pregnancy lymphocytes release a similar factor. The present study reveals the biologic significance of this finding. Treatment of BALB c mice that were 8 days pregnant with a progesterone receptor blocker (RU 486) resulted in 100% resorption of the fetuses. Simultaneous administration of the supernatant from progesterone-treated murine pregnancy spleen cells restored the resorption rate to the original 6% observed in untreated control animals. These data suggest that functional lymphocytic progesterone binding sites are needed for the maintenance of normal pregnancy. Because of the blockage of progesterone receptors and the consequent inability of the lymphocytes to produce the progesterone-induced blocking factor, abortion is initiated by immune factors. The fact that administration of the preformed blocking factor counteracted the effect of antiprogesterone treatment suggests that progesterone-mediated immunosuppression is needed for the maintenance of normal gestation.

Original languageEnglish
Pages (from-to)1320-1322
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume163
Issue number4 PART 1
DOIs
Publication statusPublished - 1990

Fingerprint

Progesterone
Progesterone Receptors
Lymphocytes
Pregnancy
Pregnancy Maintenance
Mifepristone
Immunologic Factors
Immunosuppression
blocking factor
Pregnant Women
Fetus
Spleen
Binding Sites
Maintenance
Therapeutics
Proteins

Keywords

  • abortion
  • Progesterone receptor block
  • progesterone-dependent immunomodulation

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

A progesterone-induced blocking factor corrects high resorption rates in mice treated with antiprogesterone. / Szekeres-Barthó, J.; Chaouat, G.; Kinsky, R.

In: American Journal of Obstetrics and Gynecology, Vol. 163, No. 4 PART 1, 1990, p. 1320-1322.

Research output: Contribution to journalArticle

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AB - Earlier we showed that because of the presence of functional progesterone receptors, lymphocytes of healthy pregnant women produced an immunomodulatory protein in the presence of progesterone, whereas those of nonpregnant persons did not. Progesterone-treated murine pregnancy lymphocytes release a similar factor. The present study reveals the biologic significance of this finding. Treatment of BALB c mice that were 8 days pregnant with a progesterone receptor blocker (RU 486) resulted in 100% resorption of the fetuses. Simultaneous administration of the supernatant from progesterone-treated murine pregnancy spleen cells restored the resorption rate to the original 6% observed in untreated control animals. These data suggest that functional lymphocytic progesterone binding sites are needed for the maintenance of normal pregnancy. Because of the blockage of progesterone receptors and the consequent inability of the lymphocytes to produce the progesterone-induced blocking factor, abortion is initiated by immune factors. The fact that administration of the preformed blocking factor counteracted the effect of antiprogesterone treatment suggests that progesterone-mediated immunosuppression is needed for the maintenance of normal gestation.

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