Merkel-sejtes polyomavírus mint a Merkel-sejtes carcinoma valószínu kóroka

Translated title of the contribution: A probable etiological role for Merkel cell polyomavirus in the development of Merkel cell carcinoma

Katalin Barbara Horváth, Péter Pankovics, Zita Battyáni, Endre Kálmán, Gábor Reuter

Research output: Contribution to journalArticle

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Abstract

Approximately 20% of the tumours in humans are associated with contagious viral agents. Merkel cell carcinoma is a rare and highly aggressive tumour which may originate from the epidermal stratum basale, although the origin is still controversial. This tumour is most commonly found in elderly and immunocompromised patients in sun exposed areas, especially in the head and neck regions. Merkel cell carcinoma often causes a diagnostic challenge with a dramatically increasing incidence. In 2008, a DNA tumour virus, a polyomavirus (Merkel cell polyomavirus) was detected in Merkel cell carcinomas, and this finding helped to understand the etiological background of the disease. The infectious - probably viral - etiology resulted in a paradigm shift in pathogenesis and, hopefully, in therapy as well. This review summarizes the current knowledge related to Merkel cell carcinoma and the first oncogenic human polyomavirus, the Merkel cell polyomavirus, to promote the clinical adaptation of the information.

Original languageHungarian
Pages (from-to)102-112
Number of pages11
JournalOrvosi hetilap
Volume154
Issue number3
DOIs
Publication statusPublished - Jan 1 2013

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ASJC Scopus subject areas

  • Medicine(all)

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