A practical route for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates

Katalin Molnár, László Takács, Mihály Kádár, Zsuzsanna Kardos, F. Faigl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A generally applicable, practical route was developed for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates starting from the corresponding dimethyl 2-oxoalkylphosphonates. The three-step procedure contains mild and easily scaled up transformations such as trimethylsilylation, chlorination with oxalyl chloride, and trifluoroethylation; the overall yield is ca. 50%.

Original languageEnglish
Pages (from-to)1085-1090
Number of pages6
JournalSynthesis
Volume47
Issue number8
DOIs
Publication statusPublished - Apr 1 2015

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Chlorination
oxalyl chloride

Keywords

  • demethylation
  • halogenation
  • Horner-Wadsworth-Emmons reaction
  • ketones
  • phosphorus
  • stereoselectivity
  • Z -enones

ASJC Scopus subject areas

  • Organic Chemistry
  • Catalysis

Cite this

A practical route for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates. / Molnár, Katalin; Takács, László; Kádár, Mihály; Kardos, Zsuzsanna; Faigl, F.

In: Synthesis, Vol. 47, No. 8, 01.04.2015, p. 1085-1090.

Research output: Contribution to journalArticle

Molnár, Katalin ; Takács, László ; Kádár, Mihály ; Kardos, Zsuzsanna ; Faigl, F. / A practical route for the preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates. In: Synthesis. 2015 ; Vol. 47, No. 8. pp. 1085-1090.
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AU - Kardos, Zsuzsanna

AU - Faigl, F.

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