A practical review on the measurement tools for cellular adhesion force

Rita Ungai-Salánki, Beatrix Peter, Tamás Gerecsei, Norbert Orgovan, R. Horváth, B. Szabó

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cell–cell and cell–matrix adhesions are fundamental in all multicellular organisms. They play a key role in cellular growth, differentiation, pattern formation and migration. Cell-cell adhesion is substantial in the immune response, pathogen-host interactions, and tumor development. The success of tissue engineering and stem cell implantations strongly depends on the fine control of live cell adhesion on the surface of natural or biomimetic scaffolds. Therefore, the quantitative and precise measurement of the adhesion strength of living cells is critical, not only in basic research but in modern technologies, too. Several techniques have been developed or are under development to quantify cell adhesion. All of them have their pros and cons, which has to be carefully considered before the experiments and interpretation of the recorded data. Current review provides a guide to choose the appropriate technique to answer a specific biological question or to complete a biomedical test by measuring cell adhesion.

Original languageSpanish
Pages (from-to)309-333
Number of pages25
JournalAdvances in Colloid and Interface Science
Volume269
DOIs
Publication statusPublished - Jul 1 2019

Keywords

  • Adhesion force
  • Cell adhesion
  • Force measurement techniques
  • Single cell

ASJC Scopus subject areas

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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