The preparation of bis(2,2,2-trifluoroethyl) 2-oxoalkylphosphonates by the acylation of bis(2,2,2-trifluoroethyl) methylphosphonate was re-investigated using esters rather than the sensitive acyl chlorides. Based on our optimization, the best results were achieved when the base (LiHMDS) was added to a solution of the phosphonate and the acylating agent at -90°C.
- Bis(trifluoroethyl) 2-oxoalkylphosphonate
- Carboxylic ester
- Horner-Wadsworth-Emmons reaction
- Trifluoroethyl phosphonate
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry