A possible way for prediction of domain boundaries in globular proteins from amino acid sequence

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Abstract

A simple approach to domain border prediction in globular proteins is outlined relying on the amino acid sequence only. Statistically determined sequential and association preference data of amino acids were combined to generate short range preference profiles along the polypeptide chains. Domain boundaries correlate with the minima of preference profiles, but some false minima also exist. Possibilities are discussed to exclude the false minima and to further improve the efficiency of the algorithm.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume139
Issue number1
DOIs
Publication statusPublished - Aug 29 1986

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Amino Acid Sequence
Amino Acids
Peptides
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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abstract = "A simple approach to domain border prediction in globular proteins is outlined relying on the amino acid sequence only. Statistically determined sequential and association preference data of amino acids were combined to generate short range preference profiles along the polypeptide chains. Domain boundaries correlate with the minima of preference profiles, but some false minima also exist. Possibilities are discussed to exclude the false minima and to further improve the efficiency of the algorithm.",
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