A possible mosaic form of delayed centromere separation and aneuploidy

Research output: Contribution to journalArticle

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Abstract

On average, a "normal" centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of delayed separation in the parent may account for trisomy in the offspring.

Original languageEnglish
Pages (from-to)477-478
Number of pages2
JournalHuman Genetics
Volume88
Issue number4
DOIs
Publication statusPublished - Feb 1992

Fingerprint

Chromosomes, Human, Pair 18
Mosaicism
Centromere
Trisomy
Aneuploidy
Mitosis
Trisomy 18

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

A possible mosaic form of delayed centromere separation and aneuploidy. / Méhes, K.; Kosztolányi, G.

In: Human Genetics, Vol. 88, No. 4, 02.1992, p. 477-478.

Research output: Contribution to journalArticle

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