A possible competition between 5'-monodeiodination of thyroxine and the respiratory burst in human granulocytes

J. T. Nagy, T. Szabo, I. Komáromi, I. Sztojka, G. Fóris, A. Leövey

Research output: Contribution to journalArticle

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Abstract

Thyroxine (T4) pretreatment of A 23187-stimulated human granulocytes in 10-5 - 10-6 M concentration range inhibited the superoxide anion production of these cells. T4 increased the level of oxidized form of glutathione, whereas the intracellular level of the reduced form decreased. A similar alteration in the ratio of the oxidized to reduced forms of glutathione was detected in granulocytes during yeast cell phagocytosis. In addition, conversion of T4 to triiodothryronine (T3) was also inhibited during phagocytosis. A possible competition between 5'-monodeiodination of T4 and the oxidative burst of human granulocytes is discussed.

Original languageEnglish
Pages (from-to)415-417
Number of pages3
JournalHormone and Metabolic Research
Volume18
Issue number6
Publication statusPublished - 1986

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Respiratory Burst
Thyroxine
Granulocytes
Glutathione
Superoxides
Yeast
Cytophagocytosis
Glutathione Disulfide
Cells
Calcimycin
Phagocytosis
Yeasts

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

A possible competition between 5'-monodeiodination of thyroxine and the respiratory burst in human granulocytes. / Nagy, J. T.; Szabo, T.; Komáromi, I.; Sztojka, I.; Fóris, G.; Leövey, A.

In: Hormone and Metabolic Research, Vol. 18, No. 6, 1986, p. 415-417.

Research output: Contribution to journalArticle

Nagy, J. T. ; Szabo, T. ; Komáromi, I. ; Sztojka, I. ; Fóris, G. ; Leövey, A. / A possible competition between 5'-monodeiodination of thyroxine and the respiratory burst in human granulocytes. In: Hormone and Metabolic Research. 1986 ; Vol. 18, No. 6. pp. 415-417.
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