A possible association of periodontal infectious diseases in pregnant women with isolated orofacial clefts in their children: A population-based case-control study

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Abstract

BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip ± palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalBirth Defects Research Part A - Clinical and Molecular Teratology
Volume88
Issue number6
DOIs
Publication statusPublished - 2010

Fingerprint

Periodontal Diseases
Communicable Diseases
Case-Control Studies
Pregnant Women
Mothers
Population
Cleft Palate
Pregnancy
Maternal Exposure
Cleft Lip
Parturition
Newborn Infant
Control Groups

Keywords

  • Congenital abnormalities
  • Isolated orofacial cleft
  • Maternal periodontal infectious diseases
  • Related drug treatment
  • Smoking habit

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Medicine(all)

Cite this

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title = "A possible association of periodontal infectious diseases in pregnant women with isolated orofacial clefts in their children: A population-based case-control study",
abstract = "BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip ± palate (OR with 95{\%} CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.",
keywords = "Congenital abnormalities, Isolated orofacial cleft, Maternal periodontal infectious diseases, Related drug treatment, Smoking habit",
author = "F. B{\'a}nhidy and N. {\'A}cs and E. Puh{\'o} and E. Czeizel",
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T1 - A possible association of periodontal infectious diseases in pregnant women with isolated orofacial clefts in their children

T2 - A population-based case-control study

AU - Bánhidy, F.

AU - Ács, N.

AU - Puhó, E.

AU - Czeizel, E.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip ± palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.

AB - BACKGROUND: The aim of the study was to check the association of maternal periodontal infectious disease (MPID) during pregnancy and the possible risk for birth outcomes, mainly structural birth defects: congenital abnormalities (CAs) in their children. METHODS: The population-based data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996, was evaluated. The occurrence of medically recorded MPID in the prenatal maternity logbook was compared in 22,843 cases with different CAs and 38,151 matched controls without defects. RESULTS: Twenty-one case mothers who had offspring with a CA (case group) and 17 pregnant women who delivered newborn infants without a CA (control group) had an MPID. However, of 21 cases, 6 had isolated cleft lip ± palate (OR with 95% CI: 10.7, 4.2-27.3), and 2 were affected with isolated cleft palate (7.9, 1.8-34.2). Of these 8 cases, 6 had mothers with the exposure of MPID in the critical period of these orofacial clefts, 7 mothers were visited at home, and 6 were smokers during pregnancy. CONCLUSIONS: The unexpected findings of the study showed a strong association of MPID during pregnancy with a higher risk of isolated orofacial clefts in their children.

KW - Congenital abnormalities

KW - Isolated orofacial cleft

KW - Maternal periodontal infectious diseases

KW - Related drug treatment

KW - Smoking habit

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