A population-based case-control study of isolated ocular coloboma

Gábor Vogt, E. Puhó, E. Czeizel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aims: To attempt the detection of possible etiological factors in the origin of isolated ocular, mainly iris coloboma. Methods: The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002, was used. Exposure data and family history were based on (1) prospective medical records, (2) retrospective maternal information, and (3) information obtained by regional nurses at home visit. Results: Of 46 cases, 40 were affected with iris coloboma and 19 had bilateral manifestation. The positive family history indicated a hereditary origin in 4.3% (2/46) of cases. An association was found between the isolated ocular coloboma and hydroxyethylrutoside treatment (adjusted POR with 95% CI: 5.4, 2.2-12.9). Another association was seen between isolated ocular coloboma and hypothyroidism (adjusted OR with 95% CI = 12.6, 3.0-52.7), but it was based only on two cases. Conclusions: It is necessary to study the preventable environmental factors in the origin of these ocular defects.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalOphthalmic Epidemiology
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Coloboma
Case-Control Studies
Iris
Hydroxyethylrutoside
Population
House Calls
Hypothyroidism
Medical Records
Nurses
Mothers

Keywords

  • Case-control analysis
  • Hereditary origin
  • Hydroxyethylrutoside
  • Isolated ocular coloboma

ASJC Scopus subject areas

  • Ophthalmology
  • Epidemiology

Cite this

A population-based case-control study of isolated ocular coloboma. / Vogt, Gábor; Puhó, E.; Czeizel, E.

In: Ophthalmic Epidemiology, Vol. 12, No. 3, 06.2005, p. 191-197.

Research output: Contribution to journalArticle

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