A polymorphism of the neuregulin 1 gene(SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia

Szabolcs Keri, Imre Kiss, Imola Seres, Oguz Kelemen

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33 Citations (Scopus)


A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform. The purpose of this study was to investigate the interaction between this polymorphism and reactivity to psychosocial stress. Two hundred patients with schizophrenia were geno-typed. The patients and one of their family members participated in neutral and conflict-related interactions in which the number of relatives' criticisms and patients' unusual thoughts was assessed. Patients with the risk T/T genotype expressed more unusual thoughts than C-carriers (C/T and C/C) during conflict-related interactions but not during neutral interactions. Two controls polymorphisms of the neuregulin 1 gene (rs10954867 and rs7005288) showed no such effect. These results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress.

Original languageEnglish
Pages (from-to)418-420
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number3
Publication statusPublished - Apr 5 2009



  • Expressed emotion
  • Neuregulin 1
  • Psychosocial stress
  • Rs6994992
  • Schizophrenia

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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