A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC

Z. Juvancz, K. E. Markides, C. A. Rouse, K. Jones, B. J. Tarbet, J. S. Bradshaw, M. L. Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A chiral stationary phase with a silicone backbone and substituted side chains of (S)-N-1-(1-naphthyl)-4-propyloxybenzamide substitution has been introduced for open tubular column GC and SFC. The stationary phase has a broad temperature working range (20-280°C), and provides highly efficient columns (> 3000 plates/meter). One of the key interactions for selectivity is the π-π interaction, but the stationary phase can also be used to separate enantiomers without π electrons. The phase can be used to separate a broad range of compounds, which is demonstrated by the separation of enantiomeric compounds having aromatic rings, amino acid and terpenic alcohol groups. This stationary phase expands the use of Pirkle phases into the field of open tubular column chromatography.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalEnantiomer
Volume3
Issue number2
Publication statusPublished - 1998

Fingerprint

Aromatic Amino Acids
Column chromatography
Enantiomers
Aromatic compounds
Silicones
Chromatography
Substitution reactions
Alcohols
Electrons
Amino Acids
Temperature

Keywords

  • GC
  • Pirkle type
  • Polymeric CSP
  • SFC

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Chemistry(all)
  • Organic Chemistry

Cite this

Juvancz, Z., Markides, K. E., Rouse, C. A., Jones, K., Tarbet, B. J., Bradshaw, J. S., & Lee, M. L. (1998). A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC. Enantiomer, 3(2), 89-94.

A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC. / Juvancz, Z.; Markides, K. E.; Rouse, C. A.; Jones, K.; Tarbet, B. J.; Bradshaw, J. S.; Lee, M. L.

In: Enantiomer, Vol. 3, No. 2, 1998, p. 89-94.

Research output: Contribution to journalArticle

Juvancz, Z, Markides, KE, Rouse, CA, Jones, K, Tarbet, BJ, Bradshaw, JS & Lee, ML 1998, 'A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC', Enantiomer, vol. 3, no. 2, pp. 89-94.
Juvancz Z, Markides KE, Rouse CA, Jones K, Tarbet BJ, Bradshaw JS et al. A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC. Enantiomer. 1998;3(2):89-94.
Juvancz, Z. ; Markides, K. E. ; Rouse, C. A. ; Jones, K. ; Tarbet, B. J. ; Bradshaw, J. S. ; Lee, M. L. / A polymeric high resolution Pirkle-type chiral stationary phase for GC and SFC. In: Enantiomer. 1998 ; Vol. 3, No. 2. pp. 89-94.
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AU - Bradshaw, J. S.

AU - Lee, M. L.

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