A polarographic and spectrophotometric routine analyzer for assaying content uniformity in pharmaceutical quality control

Zsófia Fehér, G. Horvai, G. Nagy, Zsuzsanna Niegreisz, K. Tóth, Ernö Pungor

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A serial analyzer with polarographic and spectrophotometric detection has been designed to speed up content uniformity tests in pharmaceutical quality control laboratories. The advantages of flow and discrete analysis are combined to provide the required speed and precision. Pharmaceutical preparations of diazepam, nitrazepam, spironolactone and pyridinolcarbamate have been tested satisfactorily. The system is easily constructed from commercially available hardware and a few home-made units. The problem of sample deaeration before polarographic measurements in flow systems is solved succesfully in a very simple way.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalAnalytica Chimica Acta
Volume145
Issue numberC
DOIs
Publication statusPublished - 1983

Fingerprint

Quality Control
quality control
Quality control
drug
Pyridinolcarbamate
Nitrazepam
Spironolactone
Diazepam
Pharmaceutical Preparations
hardware
Hardware
speed
Deaeration
test
detection
analysis
laboratory

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

A polarographic and spectrophotometric routine analyzer for assaying content uniformity in pharmaceutical quality control. / Fehér, Zsófia; Horvai, G.; Nagy, G.; Niegreisz, Zsuzsanna; Tóth, K.; Pungor, Ernö.

In: Analytica Chimica Acta, Vol. 145, No. C, 1983, p. 41-50.

Research output: Contribution to journalArticle

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