A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma: A double-blind randomized study

A. Klainguti, A. Forgacs, I. Berkes, E. Castellacci

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: This prospective, randomized, double-blind, three-arm study was performed to investigate the efficacy of a medicated plaster containing the combination of diclofenac epolamine (DHEP) 180mg and heparin 5600IU in the treatment of unilateral blunt soft tissue injuries involving the upper or lower limb, complicated by severe local haematoma. Research design and methods: Patients with mild-to-moderate injuries complicated by local haematoma (≤140cm2) were included and randomly treated once daily with plasters containing DHEP/heparin, DHEP only, or placebo. Plasters were applied for at least 12 hours daily for 10 consecutive days. Main outcome measures: The time to complete haematoma dissolution was the primary efficacy endpoint; secondary endpoints were spontaneous pain reduction, pain on movement, muscle swelling and use of rescue analgesia. Results: A total of 185 patients (90 males and 95 females, aged 1880 years) were evaluated for efficacy. Baseline clinical and demographic characteristics were similar across the treatment groups. The time to complete haematoma dissolution was significantly shorter with the DHEP/heparin plaster compared with both the DHEP and placebo plasters (p

Original languageEnglish
Pages (from-to)2243-2251
Number of pages9
JournalCurrent Medical Research and Opinion
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Sprains and Strains
Contusions
Double-Blind Method
Hematoma
Heparin
Placebos
Pain
Soft Tissue Injuries
Nonpenetrating Wounds
Analgesia
diclofenac hydroxyethylpyrrolidine
Lower Extremity
Arm
Research Design
Demography
Outcome Assessment (Health Care)
Muscles
Wounds and Injuries
Therapeutics

Keywords

  • Diclofenac epolamine
  • Haematoma
  • Heparin
  • Plaster
  • Trauma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A plaster containing DHEP and heparin for mild to moderate contusions and sprains with haematoma : A double-blind randomized study. / Klainguti, A.; Forgacs, A.; Berkes, I.; Castellacci, E.

In: Current Medical Research and Opinion, Vol. 26, No. 9, 09.2010, p. 2243-2251.

Research output: Contribution to journalArticle

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