Abstract
Manganese as an environmental neurotoxicant can cause oral exposure. Six rats were equipped with a connector crown, allowing repeated recording of electrocorticogram (ECoG) with simultaneous recording of motor activity in an open field box. Weekly one 30-min recording session was held, and after two control sessions, four of the six rats had 2.5 mg/ml manganese chloride in their drinking water. The treated rats showed higher motility during the exposure period than the untreated ones; and substantially decreased total ECoG power without marked change the spectrum. The changes of both motility and ECoG were correlated to the individual brain Mn levels, and the activity decrease during a session was correlated to the total ECoG power. These effects can be likened to early adult manganism and to symptoms of children exposed to Mn via drinking water. Repeated simultaneous recording of open field motility and spontaneous cortical activity seems suitable to detect early electrophysiological and behavioral effects of an oral neurotoxic exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 331-339 |
| Number of pages | 9 |
| Journal | International Journal of Environmental Health Research |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1 2012 |
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Keywords
- chronic recording
- electrocorticogram
- manganese
- open field
- rat
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Pollution
- Public Health, Environmental and Occupational Health
Cite this
A pilot study with simultaneous recording of changes in motility and cortical electrical activity of rats during four weeks of oral manganese exposure. / Takács, Szabolcs; Szabó, A.; Oszlánczi, Gábor; Paulik, Edit; Papp, A.
In: International Journal of Environmental Health Research, Vol. 22, No. 4, 01.08.2012, p. 331-339.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A pilot study with simultaneous recording of changes in motility and cortical electrical activity of rats during four weeks of oral manganese exposure
AU - Takács, Szabolcs
AU - Szabó, A.
AU - Oszlánczi, Gábor
AU - Paulik, Edit
AU - Papp, A.
PY - 2012/8/1
Y1 - 2012/8/1
N2 - Manganese as an environmental neurotoxicant can cause oral exposure. Six rats were equipped with a connector crown, allowing repeated recording of electrocorticogram (ECoG) with simultaneous recording of motor activity in an open field box. Weekly one 30-min recording session was held, and after two control sessions, four of the six rats had 2.5 mg/ml manganese chloride in their drinking water. The treated rats showed higher motility during the exposure period than the untreated ones; and substantially decreased total ECoG power without marked change the spectrum. The changes of both motility and ECoG were correlated to the individual brain Mn levels, and the activity decrease during a session was correlated to the total ECoG power. These effects can be likened to early adult manganism and to symptoms of children exposed to Mn via drinking water. Repeated simultaneous recording of open field motility and spontaneous cortical activity seems suitable to detect early electrophysiological and behavioral effects of an oral neurotoxic exposure.
AB - Manganese as an environmental neurotoxicant can cause oral exposure. Six rats were equipped with a connector crown, allowing repeated recording of electrocorticogram (ECoG) with simultaneous recording of motor activity in an open field box. Weekly one 30-min recording session was held, and after two control sessions, four of the six rats had 2.5 mg/ml manganese chloride in their drinking water. The treated rats showed higher motility during the exposure period than the untreated ones; and substantially decreased total ECoG power without marked change the spectrum. The changes of both motility and ECoG were correlated to the individual brain Mn levels, and the activity decrease during a session was correlated to the total ECoG power. These effects can be likened to early adult manganism and to symptoms of children exposed to Mn via drinking water. Repeated simultaneous recording of open field motility and spontaneous cortical activity seems suitable to detect early electrophysiological and behavioral effects of an oral neurotoxic exposure.
KW - chronic recording
KW - electrocorticogram
KW - manganese
KW - open field
KW - rat
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UR - http://www.scopus.com/inward/citedby.url?scp=84864675900&partnerID=8YFLogxK
U2 - 10.1080/09603123.2011.643228
DO - 10.1080/09603123.2011.643228
M3 - Article
C2 - 22182062
AN - SCOPUS:84864675900
VL - 22
SP - 331
EP - 339
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
SN - 0960-3123
IS - 4
ER -