A pilot study on faecal MMP-9: A new noninvasive diagnostic marker of colorectal cancer

Anita Annaházi, Szabolcs Ábrahám, Klaudia Farkas, András Rosztóczy, Orsolya Inczefi, Imre Földesi, Mónika Szcs, Mariann Rutka, Vassilia Theodorou, Helene Eutamene, Lionel Bueno, György Lázár, Tibor Wittmann, Tamás Molnár, Richárd Róka

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12 Citations (Scopus)

Abstract

Background:Colorectal cancer (CRC) is one of the leading malignancies worldwide, therefore cheap noninvasive screening methods are of great importance. Matrix-metalloproteinase-9 (MMP-9) has a role in the progression of CRC, and its level is elevated in tumour biopsies. Faecal MMP-9 levels are increased in active ulcerative colitis patients, but in CRC patients, they have never been measured. We aimed to assess the faecal MMP-9 levels in patients undergoing total colonoscopy according to endoscopic and histological diagnosis.Methods:One hundred and nine patients provided faecal samples for MMP-9 analysis. A total colonoscopy was performed; suspicious lesions were evaluated by histology. Faecal MMP-9 levels were measured by ELISA.Results:The number of patients allocated to different groups were: negative/diverticulosis: 34 (referred to as controls); hyperplastic polyps: 15; adenomas: 32 (22 at high risk); and CRC: 28. Faecal MMP-9 was significantly increased in CRC compared with all other groups (P<0.001). Faecal MMP-9 was suitable to distinguish CRC patients from controls (sensitivity: 89.3%; specificity: 91.2%). By means of a lower cutoff level, faecal MMP-9 identified high-risk adenomas besides CRC (sensitivity: 76%; specificity: 85.3%). This lower cutoff level screened 59% of high-risk adenomas.Conclusions:Faecal MMP-9 may be a promising new noninvasive marker in CRC.

Original languageEnglish
Pages (from-to)787-792
Number of pages6
JournalBritish journal of cancer
Volume114
Issue number7
DOIs
Publication statusPublished - Mar 1 2016

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Keywords

  • colorectal cancer
  • matrix-metalloprotease-9
  • noninvasive diagnostic marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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