A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model

Danica Matusovits, Z. Suba, D. Takács, Kinga Turzó, K. Donath, A. Fazekas

Research output: Contribution to journalArticle

Abstract

The aim of this pilot investigation was to develop a new animal model for studying the effects on osteogenesis of agents used in the guided bone regeneration technique. As test material, a mixture of two osseoconductive materials with different physico-chemical characteristics was used. One component of the mixture was Bio-Oss, a bovine hydroxyapatite; the other was Cerasorb, a synthetic tricalcium phosphate. The mixture consisited of 50 volume percent of Bio-Oss and 50 volume percent of Cerasorb. In in vivo pilot experiment, bone wounds were prepared in the proximal third of both femurs of rabbits. A Cerasorb + Bio-Oss mixture was inserted on the test side and the same amount of sterile buffered physiological solution on the control side. After healing for 4 weeks, the bone segments were embedded and cut without decalcification, using the Exact cutting and grinding system. The density of the newlyformed bone was evaluated histomorphometrically. On the Cerasorb + Bio-Oss test side the bone density was almost 1.5 times higher than that on the control side. These results demonstrated that the applied animal model is appropriate for investigation of the effects on osteogenesis of biocompatible graft materials such as Bio-Oss and Cerasorb.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalActa Biologica Hungarica
Volume59
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Osteogenesis
bone
Bone
Animals
Animal Models
animal
Bone Density
Bone and Bones
Bone Regeneration
Biocompatible Materials
Durapatite
grinding
Grafts
Femur
regeneration
phosphate
Bio-Oss
beta-tricalcium phosphate
Rabbits
Transplants

Keywords

  • Bio-Oss
  • Cerasorb
  • Histomorphometry
  • Osteogenesis
  • Rabbit model

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model. / Matusovits, Danica; Suba, Z.; Takács, D.; Turzó, Kinga; Donath, K.; Fazekas, A.

In: Acta Biologica Hungarica, Vol. 59, No. 3, 09.2008, p. 327-334.

Research output: Contribution to journalArticle

Matusovits, Danica ; Suba, Z. ; Takács, D. ; Turzó, Kinga ; Donath, K. ; Fazekas, A. / A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model. In: Acta Biologica Hungarica. 2008 ; Vol. 59, No. 3. pp. 327-334.
@article{226da637ec544cafb886135dfeeb6249,
title = "A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model",
abstract = "The aim of this pilot investigation was to develop a new animal model for studying the effects on osteogenesis of agents used in the guided bone regeneration technique. As test material, a mixture of two osseoconductive materials with different physico-chemical characteristics was used. One component of the mixture was Bio-Oss, a bovine hydroxyapatite; the other was Cerasorb, a synthetic tricalcium phosphate. The mixture consisited of 50 volume percent of Bio-Oss and 50 volume percent of Cerasorb. In in vivo pilot experiment, bone wounds were prepared in the proximal third of both femurs of rabbits. A Cerasorb + Bio-Oss mixture was inserted on the test side and the same amount of sterile buffered physiological solution on the control side. After healing for 4 weeks, the bone segments were embedded and cut without decalcification, using the Exact cutting and grinding system. The density of the newlyformed bone was evaluated histomorphometrically. On the Cerasorb + Bio-Oss test side the bone density was almost 1.5 times higher than that on the control side. These results demonstrated that the applied animal model is appropriate for investigation of the effects on osteogenesis of biocompatible graft materials such as Bio-Oss and Cerasorb.",
keywords = "Bio-Oss, Cerasorb, Histomorphometry, Osteogenesis, Rabbit model",
author = "Danica Matusovits and Z. Suba and D. Tak{\'a}cs and Kinga Turz{\'o} and K. Donath and A. Fazekas",
year = "2008",
month = "9",
doi = "10.1556/ABiol.59.2008.3.6",
language = "English",
volume = "59",
pages = "327--334",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - A pilot study of Cerasorb and Bio-Oss enhanced new bone formation in animal model

AU - Matusovits, Danica

AU - Suba, Z.

AU - Takács, D.

AU - Turzó, Kinga

AU - Donath, K.

AU - Fazekas, A.

PY - 2008/9

Y1 - 2008/9

N2 - The aim of this pilot investigation was to develop a new animal model for studying the effects on osteogenesis of agents used in the guided bone regeneration technique. As test material, a mixture of two osseoconductive materials with different physico-chemical characteristics was used. One component of the mixture was Bio-Oss, a bovine hydroxyapatite; the other was Cerasorb, a synthetic tricalcium phosphate. The mixture consisited of 50 volume percent of Bio-Oss and 50 volume percent of Cerasorb. In in vivo pilot experiment, bone wounds were prepared in the proximal third of both femurs of rabbits. A Cerasorb + Bio-Oss mixture was inserted on the test side and the same amount of sterile buffered physiological solution on the control side. After healing for 4 weeks, the bone segments were embedded and cut without decalcification, using the Exact cutting and grinding system. The density of the newlyformed bone was evaluated histomorphometrically. On the Cerasorb + Bio-Oss test side the bone density was almost 1.5 times higher than that on the control side. These results demonstrated that the applied animal model is appropriate for investigation of the effects on osteogenesis of biocompatible graft materials such as Bio-Oss and Cerasorb.

AB - The aim of this pilot investigation was to develop a new animal model for studying the effects on osteogenesis of agents used in the guided bone regeneration technique. As test material, a mixture of two osseoconductive materials with different physico-chemical characteristics was used. One component of the mixture was Bio-Oss, a bovine hydroxyapatite; the other was Cerasorb, a synthetic tricalcium phosphate. The mixture consisited of 50 volume percent of Bio-Oss and 50 volume percent of Cerasorb. In in vivo pilot experiment, bone wounds were prepared in the proximal third of both femurs of rabbits. A Cerasorb + Bio-Oss mixture was inserted on the test side and the same amount of sterile buffered physiological solution on the control side. After healing for 4 weeks, the bone segments were embedded and cut without decalcification, using the Exact cutting and grinding system. The density of the newlyformed bone was evaluated histomorphometrically. On the Cerasorb + Bio-Oss test side the bone density was almost 1.5 times higher than that on the control side. These results demonstrated that the applied animal model is appropriate for investigation of the effects on osteogenesis of biocompatible graft materials such as Bio-Oss and Cerasorb.

KW - Bio-Oss

KW - Cerasorb

KW - Histomorphometry

KW - Osteogenesis

KW - Rabbit model

UR - http://www.scopus.com/inward/record.url?scp=55849095426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55849095426&partnerID=8YFLogxK

U2 - 10.1556/ABiol.59.2008.3.6

DO - 10.1556/ABiol.59.2008.3.6

M3 - Article

C2 - 18839699

AN - SCOPUS:55849095426

VL - 59

SP - 327

EP - 334

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 3

ER -