A phase II multicenter study of two different dosages of pemetrexed given in combination with cyclophosphamide as first-line treatment in patients with locally advanced or metastatic breast cancer

Christian Dittrich, Ewa Solska, Alexey Manikhas, Alexandru Eniu, Sergei Tjulandin, Rodica Anghel, Luna Musib, Bente Frimodt-Moller, Yushan Liu, Kurt Krejcy, István Láng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pemetrexed/cyclophosphamide was evaluated as first-line treatment for patients with locally advanced/metastatic breast cancer. In this randomized phase II study (NCT00190671), therapy consisted of either 600 mg/m2 (P600) or 1,800 mg/m2 (P1800) pemetrexed, followed by 600 mg/m 2 cyclophosphamide, every 21 days; 103 females (42 P600; 61 P1800) were enrolled. P600 was discontinued, as response rate (19.1%) was lower than targeted. In the P1800 arm, 20 patients had partial response (32.8%; 95% CI: 21.044.6) and 26 (42.6%) had stable disease. Median progression-free survival was 6.3 months (range: 0.331.1). P1800 plus cyclophosphamide 600 represents a regimen of reasonable efficacy and acceptable tolerability.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalCancer Investigation
Volume30
Issue number4
DOIs
Publication statusPublished - May 2012

Keywords

  • Breast cancer
  • Failed standard adjuvant therapy
  • Multitargeted antifolate
  • Pharmacokinetics
  • Randomized phase II trial

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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