A peptide-like putative marker substance of laryngeal cancer patients

L. Tamás, I. Sziklai, O. Ribári, G. Répássy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acidic ethanol precipitation, gel-filtration chromatography (Sephadex G-25) and capillary isotachophoresis were performed on serum and tumor tissue samples from eight patients with stage III and IV laryngeal cancers. An anionic 0.3-5 kDA molecular mass substance that was probably peptide was recorded in both the serum and cancer tissue, but could not be shown in the serum of five control subjects. This substance disappeared from the sera of four patients after total laryngectomy and they have now lived without tumor recurrence for about 2 years. Three of the other four patients developed tumor recurrences while one patient has remained tumor-free. Our findings support a hypothesis that the peptide-like molecule is characteristic of laryngeal cancer and can possibly be used for monitoring the disease.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume250
Issue number3
DOIs
Publication statusPublished - Jun 1993

Fingerprint

Laryngeal Neoplasms
Peptides
Neoplasms
Serum
Isotachophoresis
Recurrence
Laryngectomy
Gel Chromatography
Ethanol

Keywords

  • Isotachophoresis
  • Laryngeal cancer
  • Peptide-like molecular substances
  • Tumor marker

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

A peptide-like putative marker substance of laryngeal cancer patients. / Tamás, L.; Sziklai, I.; Ribári, O.; Répássy, G.

In: European Archives of Oto-Rhino-Laryngology, Vol. 250, No. 3, 06.1993, p. 157-160.

Research output: Contribution to journalArticle

@article{634a09547c074564aa6c4ca19c2ea8e7,
title = "A peptide-like putative marker substance of laryngeal cancer patients",
abstract = "Acidic ethanol precipitation, gel-filtration chromatography (Sephadex G-25) and capillary isotachophoresis were performed on serum and tumor tissue samples from eight patients with stage III and IV laryngeal cancers. An anionic 0.3-5 kDA molecular mass substance that was probably peptide was recorded in both the serum and cancer tissue, but could not be shown in the serum of five control subjects. This substance disappeared from the sera of four patients after total laryngectomy and they have now lived without tumor recurrence for about 2 years. Three of the other four patients developed tumor recurrences while one patient has remained tumor-free. Our findings support a hypothesis that the peptide-like molecule is characteristic of laryngeal cancer and can possibly be used for monitoring the disease.",
keywords = "Isotachophoresis, Laryngeal cancer, Peptide-like molecular substances, Tumor marker",
author = "L. Tam{\'a}s and I. Sziklai and O. Rib{\'a}ri and G. R{\'e}p{\'a}ssy",
year = "1993",
month = "6",
doi = "10.1007/BF00171703",
language = "English",
volume = "250",
pages = "157--160",
journal = "Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde",
issn = "0003-9195",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - A peptide-like putative marker substance of laryngeal cancer patients

AU - Tamás, L.

AU - Sziklai, I.

AU - Ribári, O.

AU - Répássy, G.

PY - 1993/6

Y1 - 1993/6

N2 - Acidic ethanol precipitation, gel-filtration chromatography (Sephadex G-25) and capillary isotachophoresis were performed on serum and tumor tissue samples from eight patients with stage III and IV laryngeal cancers. An anionic 0.3-5 kDA molecular mass substance that was probably peptide was recorded in both the serum and cancer tissue, but could not be shown in the serum of five control subjects. This substance disappeared from the sera of four patients after total laryngectomy and they have now lived without tumor recurrence for about 2 years. Three of the other four patients developed tumor recurrences while one patient has remained tumor-free. Our findings support a hypothesis that the peptide-like molecule is characteristic of laryngeal cancer and can possibly be used for monitoring the disease.

AB - Acidic ethanol precipitation, gel-filtration chromatography (Sephadex G-25) and capillary isotachophoresis were performed on serum and tumor tissue samples from eight patients with stage III and IV laryngeal cancers. An anionic 0.3-5 kDA molecular mass substance that was probably peptide was recorded in both the serum and cancer tissue, but could not be shown in the serum of five control subjects. This substance disappeared from the sera of four patients after total laryngectomy and they have now lived without tumor recurrence for about 2 years. Three of the other four patients developed tumor recurrences while one patient has remained tumor-free. Our findings support a hypothesis that the peptide-like molecule is characteristic of laryngeal cancer and can possibly be used for monitoring the disease.

KW - Isotachophoresis

KW - Laryngeal cancer

KW - Peptide-like molecular substances

KW - Tumor marker

UR - http://www.scopus.com/inward/record.url?scp=0027260530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027260530&partnerID=8YFLogxK

U2 - 10.1007/BF00171703

DO - 10.1007/BF00171703

M3 - Article

C2 - 8357606

AN - SCOPUS:0027260530

VL - 250

SP - 157

EP - 160

JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde

SN - 0003-9195

IS - 3

ER -