A patient specific electro-mechanical model of the heart

Sándor M. Szilágyi, László Szilágyi, Zoltán Benyó

Research output: Contribution to journalArticle

11 Citations (Scopus)


This paper presents a patient specific deformable heart model that involves the known electrical and mechanical properties of the cardiac cells and tissue. The whole heart model comprises ten Tusscher's ventricular and Nygren's atrial cell models, the anatomical and electrophysiological model descriptions of the atria (introduced by Harrild et al.) and ventricle (given by Winslow et al.), and the mechanical model of the periodical cardiac contraction and resting phenomena proposed by Moireau et al. During the propagation of the depolarization wave, the kinetic, compositional and rotational anisotropy is handled by the tissue, organ and torso model. The applied patient specific parameters were determined by an evolutionary computation method. An intensive parameter reduction was performed using the abstract formulation of the searching space. This patient specific parameter representation enables the adjustment of deformable model parameters in real-time. The validation process was performed using simultaneously measured ECG and ultrasound image records that were compared with simulated signals and shapes using an abstract, parameterized evaluation criterion.

Original languageEnglish
Pages (from-to)183-200
Number of pages18
JournalComputer Methods and Programs in Biomedicine
Issue number2
Publication statusPublished - Feb 1 2011


  • Active appearance motion model
  • Cardiac image processing
  • Electro-mechanical heart model
  • Evolutionary computation
  • Parameter reduction
  • Patient specific analysis

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

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